Seattle jumped out to a 4-0 lead behind Noesi by the sixth inning. In the bottom of the seventh, the Indians finally got a run, but the Mariners were leading 4-1 heading into the bottom of the eighth. With two outs, Steve Delabar allowed a double to Casey Kotchman and a home run to Jose Lopez that tied the game and sent it to extra innings.
In the top of the 11th, Brandan Ryan led off with a single and was doubled home by Michael Saunders. Brandon League come on in the bottom of the inning to try for the save, but gave up two walks and a one-out single that tied the game at 5-5. League issued another walk before Carlos Santana hit a single to center field to give the Indians the walk-off win.
Noesi went 6.1 innings, allowing just one run on five hits and three walks. Justin Smoak drove in two runs for the Mariners.
The Mariners will now head into interleague play having dropped this short two-game series and have now lost four in a row, sliding past the Los Angeles Angels and into last place in the American League West for the first time this season.