The Mariners managed just six hits in the game and Toronto appeared to put the game out of reach in the bottom of the third inning, when they went up 3-0 thanks in part to a Kyle Seager error at third base.
M's starter Kevin Millwood put together a quality start, going seven innings and allowing three runs (only one earned) on seven hits and two walks, but without offense, a quality start doesn't do much good.
Things immediately got worse when Hisashi Iwakuma came in for Millwood in the bottom of the eight. Iwakuma gave up a leadoff single to Kelly Johnson and a ground-rule double to Jose Bautista. After issuing the intentional walk to Adam Lind to load the bases and set up the force out, Iwakuma immediately served up a grand slam to Edwin Encarnacion for the 7-0 Blue Jays coup de grace.
Ichiro Suzuki and Seager each had two hits, accounting for two-thirds of the Mariners' offensive output.
The M's will try for the series win in the rubber game on Sunday morning.