The Mariners got the scoring started in the top of the third inning as Kyle Seager hit a big two-out double to stake Seattle to a quick 2-0 lead.
The Twins were able to cut that lead in half in the bottom of the third on a Ben Revere sacrifice fly, but Dustin Ackley was able to deliver the knockout blow for the Mariners. Ackley belted his 10th home run of the year in the fifth inning, a three-run blast that made it 5-1 Mariners. The home run also gave the M's five hitters with double-digit home runs for the first time since 2009.
Hisashi Iwakuma was terrific, giving up an unearned run on one hit and four walks in six innings of work.
Ryan Doumit hit an RBI double in the bottom of the ninth inning, bringing the Twins another run closer, but Tom Wilhelmsen was able to get the save -- his 20th of the year.
The Mariners will try to manage the series win with a victory on Wednesday.
For more updates, stay tuned to SB Nation Seattle. For more in-depth coverage of this series, visit the Twins blog Twinkie Town and the Mariners blog Lookout Landing. For more news, notes, and analysis, check out Baseball Nation.